Regional Perfusion Therapy for Liver Cancer

Because conventional chemotherapy is not effective in treating liver cancer, regional perfusion therapy can be a viable treatment option.

Tumors of the liver can be either:

  • Primary cancers — meaning that the cancer forms first in cells in the lining of the liver.
  • Secondary cancers — meaning that the cancer has spread to the liver from another primary site. 

Surgery is usually the best method for removing early-stage liver cancer, but may not be an option when liver cancer is advanced.

Conventional chemotherapy is not very effective in treating liver cancer. Because the liver can tolerate higher doses of chemotherapy than other organs, and has a unique blood supply, it is a favorable site for the direct perfusion of chemotherapy.

Perfusion Therapy Treatments for Liver Cancer

Treatment Description

Isolated Hepatic Perfusion (IHP)

A surgical technique used to treat nonresectable liver cancers.

Percutaneous Hepatic Perfusion (PHP)

A minimally invasive procedure that uses small needle punctures in the skin to access the liver, rather than a large incision.


The goal of both types of perfusion therapy is to maximize the dose of the chemotherapy, and thereby its effectiveness in killing the cancer cells, without affecting any healthy organs or tissues near the liver.  

Additional Options for the Treatment of Liver Cancer

Learn more about additional liver cancer treatment options.