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Take Interstate 79 South. Keep left to take Interstate 279 South via Exit 72 towards Pittsburgh. Head southwest on to Interstate 579 South (Veterans Bridge). Take the Oakland/Monroeville exit toward Interstate 376 East. and merge onto Boulevard of the Allies. Continue onto Boulevard of the Allies. Take the Forbes Avenue exit, and turn left onto South Craig Street. Turn right at Centre Avenue. Hillman Cancer Center will be on your left.
Take Route 28 south to the Highland Park Bridge. Be in the left lane as you cross the bridge and follow the Washington Boulevard ramp. As you exit the ramp, shift to the right lane. Just before the traffic light, go right, onto Washington Boulevard. Travel straight through on Washington Boulevard (about two miles). At the fourth traffic light, Washington Boulevard crosses Penn Avenue and becomes Fifth Avenue. Continue on Fifth Avenue and at the light at South Aiken, turn right onto South Aiken. Stay on South Aiken to the third light (Centre Avenue) and turn left onto Centre. Just past the light at Cypress on the right is the Hillman Cancer Center driveway.
Take Route 51 north or Route 19 north through the Liberty Tunnel and cross the Liberty Bridge. Take the Bigelow Boulevard exit. At the third traffic light on Bigelow, take the left fork of the road but stay in the right lane. This puts you on Craig Street. At the second traffic light, turn left onto Centre Avenue. Continue on past the Morewood intersection and look for the Hillman Cancer Center Driveway on the left. If you reach the light at Cypress, youve gone too far down Centre Avenue.
Take westbound I-376 to exit 77 (Edgewood / Swissvale). At the end of the exit ramp, turn right onto South Braddock Avenue. Go approximately two miles and turn left onto Penn Avenue. At the intersection of Penn and Fifth Avenues, turn left onto Fifth Avenue heading west. Continue on Fifth Avenue until you reach South Aiken Avenue. Turn right onto South Aiken and continue until the third traffic light (Centre Avenue), then turn left onto Centre Avenue. Just past the light at Cypress on the right is the Hillman Cancer Center driveway.
Take PA-60 South/ US-22 East/ US-30 East following signs to Pittsburgh. Take exit 6A on the right to go on to I-376 East toward Pittsburgh. Get into the right lane before entering the Fort Pitt Tunnels; after the tunnels bear right to continue on 376 E towards Monroeville.Get off at exit 72A, Forbes Avenue / Oakland. Continue on Forbes Avenue through the University of Pittsburgh campus (Oakland section of Pittsburgh) and turn left onto S. Craig Street. From Craig, turn right onto Fifth Avenue and continue to South Aiken Avenue. At that light, turn left and follow Aiken until the third traffic light (Centre Avenue), then turn left onto Centre. Continue slowly past the light at Cypress and turn right into the Hillman Cancer Center driveway.