Octreotide

Other Names: Sandostatin®, Sandostatin LAR®

About This Drug

Sandostatin is used to treat metastatic carcinoid cancer. It can also be used to treat diarrhea. It is given as a shot into a muscle (intramuscular).

Possible Side Effects (More Common)

  • Tiredness
  • Fever
  • Itching
  • Increased blood sugar. Your doctor may have you check your blood sugar levels while you are getting this drug.
  • Slowed heart rate
  • Pain at the site of the shot
  • Constipation (not able to move bowels)

Possible Side Effects (Less Common)

  • Rash
  • Increased blood pressure
  • Abdominal cramping

Treating Side Effects

  • If you get a rash do not put anything on it unless your doctor or nurse says you may. Keep the area around the rash clean and dry. Ask your doctor for medicine if your rash bothers you.
  • If you are not able to move your bowels (constipated), check with your doctor or nurse before you use enemas, laxatives, or suppositories.
  • Drink 6-8 cups of fluids each day unless your doctor has told you to limit your fluid intake due to some other health problem. A cup is 8 ounces of fluid. If you throw up or have loose bowel movements you should drink more fluids so that you do not become dehydrated (lack water in the body due to losing too much fluid). 6-8 cups of fluids every day unless your doctor has told you to restrict your fluid intake due to another medical condition. A cup is 8 ounces of fluid. If you vomit or have diarrhea, you should drink more fluids so that you do not become dehydrated.

Food and Drug Interactions

  • There are no known serious reactions with octreotide and food. However octreotide may change your body’s ability to absorb fat in your diet.
  • This drug may interact with other medicines. Tell your doctor and pharmacist about all the medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. The safety and use of dietary supplements and alternative diets are often not known. Using these might affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's help.

When to Call the Doctor

Call your doctor or nurse right away if you have any of these symptoms:

  • Fever of 100.5°F (38.0°C) or higher
  • Increase in blood pressure if you are monitoring it at home.
  • Increase or decrease in blood sugar if you are monitoring your blood sugar at home.

Call your doctor or nurse as soon as possible if any of these symptoms happen:

  • Rash, skin irritation, or itching that is not relieved by prescribed medicines
  • Swelling of the ankles
  • Joint pain that is not relieved by prescribed medicines
  • Ongoing pain at the site of the shot
  • Cough
  • Cold symptoms that last more than 3 days
  • Abdominal cramping
  • No bowel movement in 3 days or if you feel uncomfortable

Reproduction Concerns

  • Pregnancy warning: This drug is not expected to have harmful effects on an unborn child.  Discuss the use this drug with your doctor if you are pregnant or plan to become pregnant.
  • Breast feeding warning: Octreotide passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breast feeding during treatment with this drug because this drug may enter the breast milk and badly harm a breast feeding baby.

Revised November 2014